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  • The U.S. Food and Drug Administration has approved the application of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to aid manage chronic obesity in adults with a body mass index (BMI) greater than 27, provided that they also have problems with weight-related health concerns such as Tupe2 diabestes, high cholesterol and/or hypertension (hypertension).Contrave can be a combination of two FDA-approved drugs, naltrexone and bupropion, in a extended-release formulation. Naltrexone qualifies to treat alcohol and opioid dependence. Bupropion qualifies to treat depression and seasonal affective disorder so when an aid to stopping smoking treatment.'Obesity continues to be a major public health concern,' said Jean-Marc Guettier, M.D., director of the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination with a healthy lifestyle including a reduced-calorie dieting and exercise, Contrave provides another treatment selection for chronic weight reduction for people who are obese or are overweight and still have at least one weight-related health issue.'The drug's effectiveness was evaluated in multiple many studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for just one year. All patients received lifestyle modification that contains a reduced- calorie diet and regular physical activity. Results from a medical trial that enrolled patients without diabetes showed that patients had the average weight loss of 4.1% as opposed to participants have been given placebos) within a 12- month period, while an outside study involving patients with diabetes type 2 had an average weight loss of 2% over treatment with placebo at twelve months.

    Using two separate drugs to lose weight can be very effective you will find combinations as you're watching FDA now awaiting approval. When dealing with weight-loss and the people that go through it you need to err to the side of caution and permit the FDA do its job and demand some research be done so your public knows the side effects and perils associated with the medications before we bring them. Keep in mind that drug companies come in business to generate income and that they would say almost anything to keep people on his or her medications.

    Researchers discovered that participants investing in this drug to get a year, lost weight within four weeks and have kept the weight off during the entire 56 weeks from the study. Contrave can be a combination of the drugs naltrexone and bupropion, which usually reflect a new trend of weight-loss drugs which can be made up of several active ingredient, that might make them more efficient and safer.

    Combo-pilling will be the newest fad or in addition to this the newest to come under scrutiny and thus it is just more publicly known although in the past, comb-pilling for losing weight has been around since the eighties. The biggest reason that by using a combination of pills is becoming popular is the fact that by right now there are no long term prescription diet pills that have been authorized by the FDA aside from orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications even though some of the combinations happen to be rejected or have yet to be authorized by the FDA.

    Seizures certainly are a side effect with Contrave and shouldn't be taken in individuals with seizure disorders. The drug could also raise blood pressure and heart rate, and must not be used in people with a history of cardiac arrest or stroke in the earlier six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy while using drug.

    The FDA also warned that Contrave can raise blood pressure levels and heartbeat and must stop used in patients with uncontrolled high blood pressure, as well as by anyone with heart-related and cerebrovascular (circulation dysfunction impacting mental performance) disease. Patients which has a history of cardiac event or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes with a boxed warning to alert physicians and patients on the increased likelihood of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for stop smoking.

    To keep up with the most current articles from Wendi, the Indiana Addiction Recovery Examiner, click the subscribe link on top of the page to get email notification when new content is published. Please leave a comment for just about any article.